Modulation of the packaging reaction of bacteriophage t4 terminase by DNA structure.

@article{Oram2008ModulationOT,
  title={Modulation of the packaging reaction of bacteriophage t4 terminase by DNA structure.},
  author={Mark Oram and Chandran R Sabanayagam and Lindsay W. Black},
  journal={Journal of molecular biology},
  year={2008},
  volume={381 1},
  pages={
          61-72
        }
}
Bacteriophage terminases package DNA through the portal ring of a procapsid during phage maturation. We have probed the mechanism of the phage T4 large terminase subunit gp17 by analyzing linear DNAs that are translocated in vitro. Duplex DNAs of random sequence from 20 to 500 bp were efficiently packaged. Dye and short, single-stranded end extensions were tolerated, whereas 20-base extensions, hairpin ends, 20-bp DNA-RNA hybrid, and 4-kb dsRNA substrates were not packaged. Molecules 60 bp long… CONTINUE READING
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