Modulation of the oxygen affinity of cobalt-porphyrin by globin.

  title={Modulation of the oxygen affinity of cobalt-porphyrin by globin.},
  author={M C Michael C Marden and Laurent Kiger and Claude Poyart and Abdul K. K. Rashid and Jean Kister and Françoise Stetzkowski-Marden and Giulia Caron and Masudul Haque and L. Moens},
  journal={FEBS letters},
  volume={472 2-3},
We have combined two extreme effects which influence the oxygen affinity to obtain a cobalt-based oxygen carrier with an affinity similar to that of human adult hemoglobin (HbA). The goal was to obtain an oxygen transporter with a lower oxidation rate. Exchange of the heme group (Fe-protoporphyrin IX) in Hb with a cobalt-porphyrin leads to a reduction in… CONTINUE READING