Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.

@article{Yun2002ModulationOT,
  title={Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.},
  author={Kyuson Yun and Seth M. Fischman and Jane Johnson and Martin Hrabě de Angelis and Gerry Weinmaster and John L R Rubenstein},
  journal={Development},
  year={2002},
  volume={129 21},
  pages={
          5029-40
        }
}
Notch signaling has a central role in cell fate specification and differentiation. We provide evidence that the Mash1 (bHLH) and Dlx1 and Dlx2 (homeobox) transcription factors have complementary roles in regulating Notch signaling, which in turn mediates the temporal control of subcortical telencephalic neurogenesis in mice. We defined progressively more mature subcortical progenitors (P1, P2 and P3) through their combinatorial expression of MASH1 and DLX2, as well as the expression of… CONTINUE READING
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