Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

  title={Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18},
  author={C. C. Lin and I. Orlov and A. M. Ruggiero and M. Dykes-Hoberg and A. Lee and M. Jackson and J. Rothstein},
  • C. C. Lin, I. Orlov, +4 authors J. Rothstein
  • Published 2001
  • Biology, Medicine
  • Nature
  • Excitatory amino-acid carrier 1 (EAAC1) is a high-affinity Na+-dependent l-glutamate/d, l-aspartate cell-membrane transport protein. It is expressed in brain as well as several non-nervous tissues. In brain, EAAC1 is the primary neuronal glutamate transporter. It has a polarized distribution in cells and mainly functions perisynaptically to transport glutamate from the extracellular environment. In the kidney it is involved in renal acidic amino-acid re-absorption and amino-acid metabolism… CONTINUE READING
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