Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

@article{Lin2001ModulationOT,
  title={Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18},
  author={Chien-Liang Glenn Lin and Irina Orlov and Alicia M. Ruggiero and Margaret Dykes‐Hoberg and Andy Lee and Mandy Jackson and Jeffrey D. Rothstein},
  journal={Nature},
  year={2001},
  volume={410},
  pages={84-88}
}
Excitatory amino-acid carrier 1 (EAAC1) is a high-affinity Na+-dependent l-glutamate/d, l-aspartate cell-membrane transport protein. It is expressed in brain as well as several non-nervous tissues. In brain, EAAC1 is the primary neuronal glutamate transporter. It has a polarized distribution in cells and mainly functions perisynaptically to transport glutamate from the extracellular environment. In the kidney it is involved in renal acidic amino-acid re-absorption and amino-acid metabolism… 
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Highly Influential Citations
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Background Citations
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230 Citations

The glutamate transporter excitatory amino acid carrier 1 associates with the actin-binding protein α-adducin
Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease
TLDR
An overall picture of changes in EAAT3/EAAC1 expression in health and disease is provided and several mechanisms have been described for the rapid regulation of the membrane trafficking of the transporter.
Reticulon RTN2B Regulates Trafficking and Function of Neuronal Glutamate Transporter EAAC1*
TLDR
It is shown that RTN2B, a member of the reticulon protein family that mainly localizes in the ER and ER exit sites interacts with EAAC1 and GTRAP3-18, and functions as a positive regulator in the delivery ofEAAC1 from the ER to the cell surface.
Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18
TLDR
It is demonstrated that GTRAP3-18 regulates neuronal GSH level by controlling the EAAC1-mediated uptake of cysteine, which is much lower than that of glutamate or glycine and is the rate-limiting substrate for neurons GSH synthesis.
The Endoplasmic Reticulum Exit of Glutamate Transporter Is Regulated by the Inducible Mammalian Yip6b/GTRAP3-18 Protein*
TLDR
It is demonstrated for the first time that GTRAP3-18 is a regulator of ER protein trafficking and uses hydrophobic domain interactions in the ER membrane to self-associate and cytoplasmic interactions at the C terminus to regulate trafficking.
The importance of the excitatory amino acid transporter 3 (EAAT3)
Caveolin-1 Regulates the Delivery and Endocytosis of the Glutamate Transporter, Excitatory Amino Acid Carrier 1*
TLDR
There is strong evidence that caveolin-1 contributes to the trafficking of EAAC1 on and off the plasma membrane and that these effects are associated with formation ofEAAC1-caveolin complexes.
Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.
Molecular pharmacology of glutamate transporters, EAATs and VGLUTs
Modulation of the Neural Glutamate Transporter EAAC1 by the Addicsin-interacting Protein ARL6IP1*
TLDR
It is reported that ADP-ribosylation factor-like 6 interacting protein 1 (Arl6ip1) is a novel addicsin-associated partner that indirectly promotes EAAC1-mediated glutamate transport activity in a protein kinase C activity-dependent manner.
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References

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TLDR
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TLDR
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TLDR
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