• DOI:10.1093/cercor/bhr159
• Corpus ID: 20414367

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

@article{Bourgeois2012ModulationOT,
  title={Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.},
  author={J. P. Bourgeois and Vannary Meas-Yeadid and Anne-Marie Lesourd and Philippe Faure and St{\'e}phanie Pons and Uwe Maskos and Jean Pierre Changeux and Jean-Christophe Olivo-Marin and Sylvie Granon},
  journal={Cerebral cortex},
  year={2012},
  volume={22 5},
  pages={
          1007-15
        }
}

• J. Bourgeois, Vannary Meas-Yeadid, +6 authors S. Granon
• Published 1 May 2012
• Biology, Psychology
• Cerebral cortex

Organization of locomotor behavior is altered in mice knockout for the β2 subunit of the nicotinic receptor-β2-/- mice-during novelty exploration. We investigated the neuronal basis of this alteration by measuring activation of the immediate early gene c-fos in the brains of wild-type (WT) and β2-/- mice after exploration of a novel or a familiar environment. Results show 1) no constitutive difference between WT and β2-/- mice in c-fos gene expression in any brain region, 2) novelty exploration triggered activation of the hippocampus and the reward circuit while exploration of a familiar environment produced increased activation in the amygdala, and 3) in β2-/- mice, exploration of novelty, but not familiarity, induced an increase in activation in the prelimbic prefrontal cortex (PFC) compared with WT mice. c-Fos immunoreactivity after different stages of learning in a maze increased similarly in the prelimbic area of both WT and β2-/- mice, while their performance differed. In WT mice, exploration of a novel environment triggered an increase in c-Fos expression in the reward circuit and the hippocampus, while in β2-/- mice, the amygdala and the motor cortex were additionally activated. We also highlight the role of nicotinic receptors during activation of the PFC, specifically during free exploration of a novel environment.