Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension.

@article{Amberg2003ModulationOT,
  title={Modulation of the molecular composition of large conductance, Ca(2+) activated K(+) channels in vascular smooth muscle during hypertension.},
  author={Gregory C Amberg and Adrian D. Bonev and Charles F. Rossow and Mark T. Nelson and L Fernando Santana},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 5},
  pages={717-24}
}
Hypertension is a clinical syndrome characterized by increased vascular tone. However, the molecular mechanisms underlying vascular dysfunction during acquired hypertension remain unresolved. Localized intracellular Ca2+ release events through ryanodine receptors (Ca2+ sparks) in the sarcoplasmic reticulum are tightly coupled to the activation of large-conductance, Ca2+-activated K+ (BK) channels to provide a hyperpolarizing influence that opposes vasoconstriction. In this study we tested the… CONTINUE READING

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