Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.

@article{EnquistNewman2008ModulationOT,
  title={Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.},
  author={Maria Enquist-Newman and Matt Sullivan and David O. Morgan},
  journal={Molecular cell},
  year={2008},
  volume={30 4},
  pages={437-46}
}
The completion of mitosis depends on protein ubiquitination by the anaphase-promoting complex (APC). The APC is activated by association with Cdc20 in midmitosis and Cdh1 in late mitosis and G1. Here, we show that in budding yeast the activation of APC(Cdh1) is controlled in part by destruction of the Cdh1 inhibitor Acm1. We find that Acm1 uses pseudosubstrate and other sequence motifs to bind and inhibit Cdh1, but not Cdc20. Acm1 also contains a destruction sequence that promotes its… CONTINUE READING

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