Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

Abstract

We have studied the induction of the mitochondrial cyclosporin A-sensitive permeability transition pore (PTP) by the bifunctional SH group reagent phenylarsine oxide (PhAsO). Addition of nanomolar concentrations of the electroneutral H(+)-K+ ionophore nigericin to nonrespiring mitochondria in sucrose medium determines a dramatic increase of the time… (More)

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Cite this paper

@article{Bernardi1992ModulationOT, title={Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.}, author={Paolo Bernardi and Stefano Vassanelli and P Keith Veronese and Raffaele Colonna and Ildik{\'o} Szab{\'o} and Mario Zoratti}, journal={The Journal of biological chemistry}, year={1992}, volume={267 5}, pages={2934-9} }