Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke

@inproceedings{Sun2009ModulationOT,
  title={Modulation of the major histocompatibility complex by neural stem cell-derived neurotrophic factors used for regenerative therapy in a rat model of stroke},
  author={Chong Sun and H Zhang and Jin Li and Hua Huang and Hongbin Cheng and Yajie Wang and Ping Li and Yi-hua An},
  booktitle={Journal of Translational Medicine},
  year={2009}
}
The relationship between functional improvements in ischemic rats given a neural stem cell (NSC) transplant and the modulation of the class I major histocompatibility complex (MHC) mediated by NSC-derived neurotrophins was investigated. The levels of gene expression of nerve growth factor (NGF), brain-derived neurotropic factor (BDNF) and neurotrophin-3 (NT-3) were assayed from cultures of cortical NSC from Sprague-Dawley rat E16 embryos. The levels of translated NGF in spent culture media from… CONTINUE READING