Modulation of the light response by cAMP in Drosophila photoreceptors.

  title={Modulation of the light response by cAMP in Drosophila photoreceptors.},
  author={Sylwester Chyb and Wulf Hevers and Michael Forte and William J. Wolfgang and Zvi Selinger and Roger C. Hardie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={19 20},
Phototransduction in Drosophila is mediated by a G-protein-coupled phospholipase C transduction cascade in which each absorbed photon generates a discrete electrical event, the quantum bump. In whole-cell voltage-clamp recordings, cAMP, as well as its nonhydrolyzable and membrane-permeant analogs 8-bromo-cAMP (8-Br-cAMP) and dibutyryl-cAMP, slowed down the… CONTINUE READING