Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.

@article{Janneh2005ModulationOT,
  title={Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.},
  author={Omar Janneh and Andrew Owen and Becky Chandler and Ruben C. Hartkoorn and Charles A. Hart and Patrick G. Bray and Stephen A Ward and David J. Back and Saye Khoo},
  journal={AIDS},
  year={2005},
  volume={19 18},
  pages={2097-102}
}
BACKGROUND The efflux transporters P-glycoprotein (P-gp), multidrug resistance-associated proteins (MRP) and breast cancer resistance protein (BCRP) limit the accumulation of antiretrovirals in cell lines but it is more important to know whether the expression of these transporters in peripheral blood mononuclear cells (PBMC) impacts cellular drug concentrations. OBJECTIVES To study the transport and accumulation of saquinavir (SQV) in PBMC and the effects of specific inhibitors of MRP1, MRP2… CONTINUE READING

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