Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid.

@article{Inagaki2012ModulationOT,
  title={Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid.},
  author={Sayaka Inagaki and Rodolfo Ghirlando and Jim F. White and Jelena Gvozdenovic-Jeremic and John K. Northup and Reinhard Grisshammer},
  journal={Journal of molecular biology},
  year={2012},
  volume={417 1-2},
  pages={95-111}
}
Membrane lipids have been implicated to influence the activity of G-protein-coupled receptors (GPCRs). Almost all of our knowledge on the role of lipids on GPCR and G protein function comes from work on the visual pigment rhodopsin and its G protein transducin, which reside in a highly specialized membrane environment. Thus, insight gained from rhodopsin signaling may not be simply translated to other nonvisual GPCRs. Here, we investigated the effect of lipid head group charges on the signal… CONTINUE READING
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