Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.

@article{Thatch2008ModulationOT,
  title={Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease.},
  author={Keith A. Thatch and Marshall Z. Schwartz and Edward Y. Yoo and Kim G. Mendelson and Duane S. Duke},
  journal={Journal of pediatric surgery},
  year={2008},
  volume={43 12},
  pages={
          2169-73
        }
}
BACKGROUND/PURPOSE The major side effect of total parenteral nutrition is liver injury leading to liver failure. This study was designed to assess specific growth factors in modulating the hepatic response in an ANIT-induced liver-injury model. METHODS Sprague-Dawley rats were divided into four groups: control (n = 5), liver-injury control (alpha-naphthylisothiocyanate [ANIT], 100 mg/kg, n = 8), ANIT + epidermal growth factor (EGF, 150 mug/kg per day, n = 10), and ANIT + hepatocyte growth… CONTINUE READING
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