Modulation of the hyperpolarization-activated Cl- current in human intestinal T84 epithelial cells by phosphorylation.

@article{Fritsch1996ModulationOT,
  title={Modulation of the hyperpolarization-activated Cl- current in human intestinal T84 epithelial cells by phosphorylation.},
  author={Janine Fritsch and Aleksander Edelman},
  journal={The Journal of physiology},
  year={1996},
  volume={490 ( Pt 1)},
  pages={
          115-28
        }
}
1. Hyperpolarization-activated Cl- currents (ICl,hyp) were investigated in the T84 human adenocarcinoma cell line, using the patch-clamp whole-cell configuration. 2. During whole-cell recording with high-chloride and ATP-containing internal solutions, hyperpolarizing jumps from a holding potential of 0 mV elicited slow inward current relaxations, carried by Cl- and detected at membrane potentials more negative than -40 mV. Analysis of the relative permeabilities to monovalent anions gave the… CONTINUE READING
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