Modulation of the human glucocorticoid receptor function by antidepressive compounds.

  title={Modulation of the human glucocorticoid receptor function by antidepressive compounds.},
  author={Miho Okuyama-Tamura and Masahiko Mikuni and Itaru Kojima},
  journal={Neuroscience letters},
  volume={342 3},
Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained translocation of GR into the nucleus of human lymphocytes. In contrast, major and minor tranquilizers, lithium and verapamil, a blocker of membrane steroid transporter, were without… CONTINUE READING


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