Modulation of the growth hormone–insulin-like growth factor (GH–IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: An emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review

@article{Scarth2006ModulationOT,
  title={Modulation of the growth hormone–insulin-like growth factor (GH–IGF) axis by pharmaceutical, nutraceutical and environmental xenobiotics: An emerging role for xenobiotic-metabolizing enzymes and the transcription factors regulating their expression. A review},
  author={James P. Scarth},
  journal={Xenobiotica},
  year={2006},
  volume={36},
  pages={119 - 218}
}
  • J. Scarth
  • Published 1 February 2006
  • Biology, Medicine
  • Xenobiotica
The growth hormone–insulin-like growth factor (GH–IGF) axis has gained considerable focus over recent years. One cause of this increased interest is due to a correlation of age-related decline in plasma GH/IGF levels with age-related degenerative processes, and it has led to the prescribing of GH replacement therapy by some practitioners. On the other hand, however, research has also focused on the pro-carcinogenic effects of high GH–IGF levels, providing strong impetus for finding regimes that… 
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