Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases

@inproceedings{Gardoni2015ModulationOT,
  title={Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases},
  author={Fabrizio Gardoni and Camilla Bellone},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms… CONTINUE READING

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