Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.

Abstract

MDR1 P-glycoprotein in membranes of human tumor cells of the CEM/VBL100 line was selectively labelled using photoreactive analogs of verapamil, N-(p-azido-3-[125I]salicyl)amino-verapamil ([125I]ASA-V) and prazosin, 2-[4-(4-azido-3-[125I]iodobenzoyl)piperazin-1-yl]4 -amino-6,7-dimethoxyyquinazoline ([125I]ASA-P). Mefloquine, a quinolinemethanol antimalarial… (More)

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@article{Riffkin1996ModulationOT, title={Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.}, author={Christopher D Riffkin and Robert Chung and Dominic M. P. Wall and John R Zalcberg and Alan F Cowman and M. Foley and Larry P Tilley}, journal={Biochemical pharmacology}, year={1996}, volume={52 10}, pages={1545-52} }