Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.

@article{Wilson1988ModulationOT,
  title={Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.},
  author={Emily M F Wilson and Elaine Ying Wang and Richard E Mullins and D J Uhlinger and Dennis C Liotta and J. David Lambeth and Alfred H. Merrill},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 19},
  pages={9304-9}
}
Because free long-chain bases have been recently found to have potent pharmacological effects when added to neutrophils (Wilson, E., Olcott, M. C., Bell, R. M., Merrill, A. H., Jr., and Lambeth, J. D. (1986) J. Biol. Chem. 261, 12616-12623) and other cell types, the levels in human neutrophils were measured by high-performance liquid chromatography. Sphingosine was the major free long-chain base in freshly isolated cells and ranged from 13 to 101 pmol/10(7) cells for different donors (mean… CONTINUE READING