Modulation of the delayed rectifier K+ current by isoprenaline in bull-frog atrial myocytes.

@article{Giles1989ModulationOT,
  title={Modulation of the delayed rectifier K+ current by isoprenaline in bull-frog atrial myocytes.},
  author={Wayne R Giles and Tadashi Nakajima and Kyoichi Ono and Erwin F. Shibata},
  journal={The Journal of physiology},
  year={1989},
  volume={415},
  pages={233-49}
}
1. The effects of isoprenaline (ISO) on the calcium current (ICa) and delayed rectifier K+ current (IK) were examined using a tight-seal whole-cell voltage-clamp technique in single cells from bull-frog atrium to examine the ionic mechanism(s) of catecholamine-induced action potential shape changes. 2. The effects of ISO on the action potential were dose-dependent. Very low doses (5 x 10(-9) M) prolonged the action potential. Higher doses (10(-6) M) of ISO increased the plateau height, but… CONTINUE READING

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