Modulation of the default-mode network between rest and task in Alzheimer's Disease.

@article{Schwindt2013ModulationOT,
  title={Modulation of the default-mode network between rest and task in Alzheimer's Disease.},
  author={Graeme C. Schwindt and Simone Chaudhary and David Crane and Anoop Ganda and Mario Masellis and Cheryl L. Grady and Bojana Stefanovic and Sandra E. Black},
  journal={Cerebral cortex},
  year={2013},
  volume={23 7},
  pages={1685-94}
}
Default-mode network (DMN) connectivity at rest is disrupted in Alzheimer's Disease (AD), but it is unknown whether this abnormality is a static feature, or if it varies across cognitive states. We measured DMN integrity in 16 patients with mild AD and 18 controls during resting state and a simple visual task. Patients showed resting-state deficits in the parahippocampal gyrus and posterior cingulate. No group differences were found during the task. Controls exhibited higher DMN connectivity of… CONTINUE READING
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