Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network.

@article{Williams2011ModulationOT,
  title={Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network.},
  author={Kevin W. Williams and Michael M. Scott and Joel K Elmquist},
  journal={European journal of pharmacology},
  year={2011},
  volume={660 1},
  pages={2-12}
}
Over the past century, prevalent models of energy and glucose homeostasis have been developed from a better understanding of the neural circuits underlying obesity and diabetes. From the early hypothalamic lesion reports to the more recent pharmacological and molecular/genetic studies, the hypothalamic melanocortin system has been shown to play a critical role in the regulation of metabolism. This review attempts to highlight contributions to our current understanding of how numerous… CONTINUE READING

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