Modulation of the catabolic effects of interleukin-1 beta on human articular chondrocytes by transforming growth factor-beta.

@article{Lum1996ModulationOT,
  title={Modulation of the catabolic effects of interleukin-1 beta on human articular chondrocytes by transforming growth factor-beta.},
  author={Z P Lum and B E Hakala and John S. Mort and Anneliese D. Recklies},
  journal={Journal of cellular physiology},
  year={1996},
  volume={166 2},
  pages={351-9}
}
The effects of IL-1 beta and TGF-beta on the biosynthesis of extracellular matrix structural components relative to the metalloproteinases and their inhibitor TIMP1 in human articular chondrocytes were investigated. It has been proposed that TGF-beta, acting as a positive regulator of matrix accretion, can counteract the increased loss of cartilage matrix induced by IL-1 beta. To allow a comparison of their effects on mRNA levels for these different components, quantitation by competitive RT… CONTINUE READING