Modulation of the cardiac sodium current by inhalational anesthetics in the absence and presence of beta-stimulation.


BACKGROUND Cardiac dysrhythmias during inhalational anesthesia in association with catecholamines are well known, and halothane is more "sensitizing" than isoflurane. However, the underlying mechanisms of action of volatile anesthetics with or without catecholamines on cardiac Na channels are poorly understood. In this study, the authors investigated the… (More)


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