Modulation of the activity of acetyl-CoA carboxylase and other lipogenic enzymes by growth hormone, insulin and dexamethasone in sheep adipose tissue and relationship to adaptations to lactation.

@article{Vernon1991ModulationOT,
  title={Modulation of the activity of acetyl-CoA carboxylase and other lipogenic enzymes by growth hormone, insulin and dexamethasone in sheep adipose tissue and relationship to adaptations to lactation.},
  author={Richard G. Vernon and Michael C Barber and E B Finley},
  journal={The Biochemical journal},
  year={1991},
  volume={274 ( Pt 2)},
  pages={543-8}
}
The mechanisms whereby growth hormone and dexamethasone modulate the stimulation of fatty acid synthesis by insulin in adipose tissue from lactating and non-lactating sheep have been investigated. Maintenance of adipose tissue from wethers (castrated male sheep) in tissue culture for 24 or 48 h with insulin resulted in an increased proportion of acetyl-CoA carboxylase being present in the active state; this effect was enhanced by dexamethasone and was antagonized by growth hormone. Lactation… CONTINUE READING

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