Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells

@inproceedings{Zuccarini2017ModulationOT,
  title={Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells},
  author={Mariachiara Zuccarini and Patricia Giuliani and Silvana Buccella and Valentina Di Liberto and Giuseppa Mud{\`o} and Natale Belluardo and Marzia Carluccio and Margherita Rossini and Daniele Filippo Condorelli and Michel Piers Rathbone and Francesco Caciagli and Renata Ciccarelli and Patrizia Di Iorio},
  booktitle={Purinergic Signalling},
  year={2017}
}
Epithelial to mesenchymal transition (EMT) occurs during embryogenesis or under pathological conditions such as hypoxia, injury, chronic inflammation, or tissue fibrosis. In renal tubular epithelial cells (MDCK), TGF-β1 induces EMT by reducing or increasing epithelial or mesenchymal marker expression, respectively. In this study, we confirmed that the cAMP analogues, 8-CPT-cAMP or N6-Ph-cAMP, inhibited the TGF-β1-driven overexpression of the mesenchymal markers ZEB-1, Slug, Fibronectin, and… CONTINUE READING

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