Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments.

@article{Ballent2006ModulationOT,
  title={Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments.},
  author={M Ballent and Adri{\'a}n Luis Lifschitz and Guillermo L Virkel and Juan Manuel Sallovitz and Carlos E. Lanusse},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 3},
  pages={457-63}
}
The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of ivermectin (IVM), an antiparasitic widely used in human and veterinary medicine. The work included the evaluation of two different P-gp modulators [itraconazole (ITZ) and valspodar (PSC833)] used at equimolar doses in the rat. Furthermore, the influence of both P-gp modulator agents on the disposition kinetics of IVM in plasma, liver, and gastrointestinal tissues was characterized… CONTINUE READING

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