Modulation of the Micro-environmental Ph and Its Influence on the Gel Layer Behavior and Release of Theophylline from Hydrophilic Matrices


The specific aim of this study was to develop a pH independent controlled release system for the basic drug, theopylline. The release of the drug was investigated in vitro from hydrophilic swellable matrices composed of hydroxyethyl cellulose and Eudragit S100. The micro-environmental pH of the hydrated gel layer of the matrices was manipulated by the… (More)

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