Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.

@article{Thulin2001ModulationOT,
  title={Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.},
  author={Craig D. Thulin and Justin R Savage and Joseph N McLaughlin and Steven M. Truscott and William M. Old and Natalie G Ahn and Katheryn A. Resing and Heidi E. Hamm and Mark W. Bitensky and Barry M. Willardson},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={23805-15}
}
Phototransduction is a canonical G protein-mediated cascade of retinal photoreceptor cells that transforms photons into neural responses. Phosducin (Pd) is a Gbetagamma-binding protein that is highly expressed in photoreceptors. Pd is phosphorylated in dark-adapted retina and is dephosphorylated in response to light. Dephosphorylated Pd binds Gbetagamma with high affinity and inhibits the interaction of Gbetagamma with Galpha or other effectors, whereas phosphorylated Pd does not. These results… CONTINUE READING
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