Modulation of the Endocannabinoid System: Vulnerability Factor and New Treatment Target for Stimulant Addiction

  title={Modulation of the Endocannabinoid System: Vulnerability Factor and New Treatment Target for Stimulant Addiction},
  author={Stéphanie Olière and Antoine Jolette-Riopel and St{\'e}phane Potvin and Didier Jutras-Aswad},
  journal={Frontiers in Psychiatry},
Cannabis is one of the most widely used illicit substance among users of stimulants such as cocaine and amphetamines. Interestingly, increasing recent evidence points toward the involvement of the endocannabinoid system (ECBS) in the neurobiological processes related to stimulant addiction. This article presents an up-to-date review with deep insights into the pivotal role of the ECBS in the neurobiology of stimulant addiction and the effects of its modulation on addictive behaviors. This… 

Tables from this paper

Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence

A limited number of preclinical studies suggest that CBD may have therapeutic properties on opioid, cocaine, and psychostimulant addiction, and some preliminary data suggest that it may be beneficial in cannabis and tobacco addiction in humans.

TAAR1 and Psychostimulant Addiction

Although further investigations are in need to address certain concerns and the underlying neural mechanisms, TAAR1 agonists appear to be a promising pharmacotherapy to treat psychostimulant addiction and prevent relapse.

Interactions of Cannabis and Amphetamine-Type Stimulants

This chapter reviews the available evidence on these potential interactions of cannabis and ATSs and outlines some key mechanisms that may account for the mutual modulatory influence of these substances.

Cannabinoids negatively modulate striatal glutamate and dopamine release and behavioural output of acute d-amphetamine


This review summarizes the latest experimental data concerning the potential significance of the endoge nous cannabinoid system and cannabinoids in the treatment of epilepsy and proves the anticonvulsive properties of these substances in various in vitro and in vivo models of epilepsy.



The role of endocannabinoid transmission in cocaine addiction

  • J. Arnold
  • Biology, Psychology
    Pharmacology Biochemistry and Behavior
  • 2005

Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.

The role of CB1 receptors in psychostimulant addiction

Results of studies using cannabinoid receptor subtype 1 (CB1) knockout mice as well as CB1 antagonists to elucidate the role of this neurotransmitter system in psychostimulant addiction suggest that modulators of the eCB system represent a promising novel type of therapy to treat drug addiction.

Monoamine transporters and psychostimulant addiction.

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

A comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy is provided.

Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances

CBD attenuated heroin-seeking behavior reinstated by exposure to a conditioned stimulus cue and may be a potential treatment for heroin craving and relapse, highlighting the unique contributions of distinct cannabis constituents to addiction vulnerability.

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine.

The results indicate that cannabinoids may interfere with brain reward systems responsible for the expression of acute reinforcing/rewarding properties of cocaine, and provide further evidence that the cannabinoid system could be explored as a potential drug discovery target for the treatment of psychostimulant addiction and pathological states associated with psychomotor overexcitability.