Modulation of the Barrier Function of the Skin

  title={Modulation of the Barrier Function of the Skin},
  author={Jonathan Hadgraft},
  journal={Skin Pharmacology and Physiology},
  pages={72 - 81}
  • J. Hadgraft
  • Published 2001
  • Chemistry, Medicine
  • Skin Pharmacology and Physiology
Transport of xenobiotics across the stratum corneum, the rate-controlling membrane of skin, is slow and the mechanism appears complex. However, the basic transfer is controlled by fundamental physicochemical concepts, the predominant of which are partition (K), diffusion (D) and solubility (Cs). In order to change the rate of penetration it is therefore clear that it is these parameters that should be targeted. In most instances enhancement strategies are adopted to improve D, K or Cs, however… Expand
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