Modulation of the Activity of Sp Transcription Factors by Mithramycin Analogues as a New Strategy for Treatment of Metastatic Prostate Cancer

@inproceedings{Malek2012ModulationOT,
  title={Modulation of the Activity of Sp Transcription Factors by Mithramycin Analogues as a New Strategy for Treatment of Metastatic Prostate Cancer},
  author={Anastasia Malek and L N{\'u}{\~n}ez and Marco Magistri and Lara Brambilla and Sandra Jovic and Giuseppina M. Carbone and Francisco Mor{\'i}s and Carlo Vittorio Catapano},
  booktitle={PloS one},
  year={2012}
}
Deregulated activity of transcription factors (TFs) of the Sp/KLF family, like Sp1, Sp3 and Sp4, and consequent over-expression of Sp-regulated genes occur frequently in human cancers. This provides the rationale for development of inhibitors of Sp TFs as cancer therapeutics. Mithramycin A (MTM-A) is a natural polyketide that binds GC-rich DNA sequences, inhibits activity of Sp TFs and exhibits potent antitumor activity in experimental systems. However, clinical use of MTM-A is limited by the… CONTINUE READING

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