Modulation of the 5-lipoxygenase activity of MC-9 mast cells: activation by hydroperoxides.

@article{Bryant1986ModulationOT,
  title={Modulation of the 5-lipoxygenase activity of MC-9 mast cells: activation by hydroperoxides.},
  author={Robert W. Bryant and H. D. Nsiama She and KwokeiJ. Ng and Marvin Siegel},
  journal={Prostaglandins},
  year={1986},
  volume={32 4},
  pages={
          615-27
        }
}
In order to identify regulatory steps in leukotriene synthesis, the biochemical characteristics of a 5-lipoxygenase activity in the 100,000 xg supernatant from sonicates of cells of an IL-3 dependent murine mast cell clone, MC-9 were determined. Principal products from exogenous 14C-arachidonic acid were identified as leukotriene B4, diastereomeric 5,12-dihydroxy-eicosatetraenoic acids (5,12 diHETEs) 5-hydroperoxy and hydroxyeicosatetraenoic acids (5-HPETE and 5-HETE) as well as a novel… CONTINUE READING
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