Modulation of tendon healing by nitric oxide

@article{Murrell1997ModulationOT,
  title={Modulation of tendon healing by nitric oxide},
  author={George A. C. Murrell and Csaba Szab{\'o} and Jo Ann Hannafin and D. Jang and Michelle M. Dolan and X.-H. Deng and D{\'e}d{\'e}e F Murrell and Russell F. Warren},
  journal={Inflammation Research},
  year={1997},
  volume={46},
  pages={19-27}
}
Nitric oxide (NO.) is a small, diffusible free radical that is generated from L-arginine by a family of enzymes, collectively termed the nitric oxide synthases. We investigated the role of NO. in tendon healing. NO. synthase activity and immunoreactivity was absent in un-injured rat Achilles tendon. After surgical division there was a five-fold increase in NO. synthase activity and immunoreactivity within the healing tendon at day 7, with a return to near baseline levels at day 14. Inhibition… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 20 references

Effects of immobilization on Achilles tendon healing in a rat model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 1994
View 1 Excerpt

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

Proceedings of the National Academy of Sciences of the United States of America • 1994
View 1 Excerpt

Regulation of biosynthesis of nitric oxide.

The Journal of biological chemistry • 1994
View 1 Excerpt

Achilles tendon healing: a correlation between functional and mechanical performance in the rat.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 1993
View 2 Excerpts

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