Modulation of telomere terminal structure by telomerase components in Candida albicans

@article{SteinbergNeifach2006ModulationOT,
  title={Modulation of telomere terminal structure by telomerase components in Candida albicans},
  author={Olga Steinberg-Neifach and Neal F Lue},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={2710 - 2722}
}
The telomerase ribonucleoprotein in Candida albicans is presumed to contain at least three Est proteins: CaEst1p, CaEst2p/TERT and CaEst3p. We constructed mutants missing each of the protein subunit of telomerase and analyzed overall telomere dynamics and single-stranded telomere overhangs over the course of many generations. The est1-DeltaDelta mutant manifested abrupt telomere loss and recovery, consistent with heightened recombination. Both the est2-DeltaDelta and est3-DeltaDelta mutant… CONTINUE READING