Modulation of target enzyme associated with the action of antifolates.

Abstract

The cytotoxicity and molecular effects of antifolate thymidylate synthase inhibitor, ICI-D1694, against human ileocecal carcinoma, were evaluated. The drug concentration for 50% inhibition of cell growth by ICI-D1694 is 73 nM and 3 nM following 2 hr and 72 hr exposure, respectively. The drug induces high level of DNA single strand breaks in a time dependent… (More)

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@article{Rustum1994ModulationOT, title={Modulation of target enzyme associated with the action of antifolates.}, author={Youcef M. Rustum and Shu Cao and M. B. Yin}, journal={Advances in enzyme regulation}, year={1994}, volume={34}, pages={57-70} }