Modulation of synaptic plasticity by brain estrogen in the hippocampus.

  title={Modulation of synaptic plasticity by brain estrogen in the hippocampus.},
  author={Hideo Mukai and Tetsuya Kimoto and Yasushi Hojo and S Kawato and Gen Murakami and Shimpei Higo and Yusuke Hatanaka and Mari Ogiue-Ikeda},
  journal={Biochimica et biophysica acta},
  volume={1800 10},
The hippocampus is a center for learning and memory as well as a target of Alzheimer's disease in aged humans. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. Because the local synthesis of estrogen occurs in the hippocampus of both sexes, in addition to the estrogen supply from the gonads, its functions are attracting much attention. Hippocampal estrogen modulates memory-related synaptic plasticity not only slowly but also… CONTINUE READING