Modulation of synaptic and channel activities in the respiratory network of the mice by NO/cGMP signalling pathways

@article{Mironov2007ModulationOS,
  title={Modulation of synaptic and channel activities in the respiratory network of the mice by NO/cGMP signalling pathways},
  author={Sergej L. Mironov and Kersten Langohr},
  journal={Brain Research},
  year={2007},
  volume={1130},
  pages={73-82}
}
We examined signalling pathways which can involve NO as a second messenger in the respiratory network. In the functional slice preparation, NO donors depressed the respiratory motor output and enhanced its depression after brief episodes of hypoxia. In the inspiratory neurons, NO donors suppressed spontaneous excitatory and inhibitory synaptic currents, activated single K(ATP) channels and inhibited L-type Ca2+ channels. NO scavengers, PTIO and hemoglobin, and the blocker of NO synthase, N… CONTINUE READING

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