Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat

@article{Egerton2008ModulationOS,
  title={Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat},
  author={Alice Egerton and Rabia Shabir Ahmad and Ella Hirani and Paul M. Grasby},
  journal={Psychopharmacology},
  year={2008},
  volume={200},
  pages={487-496}
}
RationaleAntagonism at serotonin 5-HT2A and 5-HT2C receptors modulates cortical and striatal dopamine (DA) release and may underlie some aspects of the clinical efficacy of ‘atypical’ antipsychotic compounds. However, it is not known whether 5-HT2A/2C receptor-mediated modulation of DA release can be quantified with non-invasive neurochemical imaging, as would be required for investigation of these processes in man.ObjectiveThe objective of the study was to perform a feasibility study in the… 

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