Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice

@article{Phan1999ModulationOS,
  title={Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice},
  author={V. Phan and T. Su and A. Privat and T. Maurice},
  journal={European Journal of Neuroscience},
  year={1999},
  volume={11}
}
  • V. Phan, T. Su, +1 author T. Maurice
  • Published 1999
  • Chemistry, Medicine
  • European Journal of Neuroscience
  • The interaction between neurosteroids and sigma1 (σ1) receptors may be of therapeutic interest during physiological or pathological ageing, particularly concerning their neuromodulatory role on cognitive functions. Neurosteroids modulate memory processes through a mechanism involving interactions with GABAA, N‐methyl‐ d‐aspartate and/or σ1 receptors. To measure the contribution of endogenous neurosteroid levels to the antiamnesic effects of σ1 agonists, we investigated the effects of inhibitors… CONTINUE READING
    48 Citations
    Strain differences in σ1 receptor‐mediated behaviours are related to neurosteroid levels
    • 39
    • Highly Influenced
    Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
    • 58

    References

    SHOWING 1-10 OF 109 REFERENCES
    Neurosteroids in the mouse brain: Behavioral and pharmacological effects of a 3β-hydroxysteroid dehydrogenase inhibitor
    • 47
    • Highly Influential
    Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
    • 283
    • PDF
    Neurosteroids in the Hippocampus: Neuronal Plasticity and Memory.
    • 41
    Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnanolone
    • 68
    Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
    • M. Bowlby
    • Chemistry, Medicine
    • Molecular pharmacology
    • 1993
    • 201
    Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.
    • 422
    • PDF
    Neurosteroids: Expression of Functional 3β‐Hydroxysteroid Dehydrogenase by Rat Sensory Neurons and Schwann Cells
    • 77
    • Highly Influential
    Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.
    • 2,104
    • PDF