Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice

@article{Phan1999ModulationOS,
  title={Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ1 receptor‐mediated behaviour in mice},
  author={V. Phan and T. Su and A. Privat and T. Maurice},
  journal={European Journal of Neuroscience},
  year={1999},
  volume={11}
}
  • V. Phan, T. Su, +1 author T. Maurice
  • Published 1999
  • Chemistry, Medicine
  • European Journal of Neuroscience
    • The interaction between neurosteroids and sigma1 (σ1) receptors may be of therapeutic interest during physiological or pathological ageing, particularly concerning their neuromodulatory role on cognitive functions. Neurosteroids modulate memory processes through a mechanism involving interactions with GABAA, N‐methyl‐ d‐aspartate and/or σ1 receptors. To measure the contribution of endogenous neurosteroid levels to the antiamnesic effects of σ1 agonists, we investigated the effects of inhibitors… CONTINUE READING
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    48 Citations
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