Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.

@article{Biswas2008ModulationOS,
  title={Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.},
  author={Saibal K Biswas and Irfan Rahman},
  journal={Molecular nutrition & food research},
  year={2008},
  volume={52 9},
  pages={987-94}
}
The expression of NF-kappaB (NF-kappaB)-dependent pro-inflammatory genes in response to oxidative stress is regulated by the acetylation-deacetylation status of histones bound to the DNA. It has been suggested that in severe asthma and in chronic obstructive pulmonary disease (COPD) patients, oxidative stress not only activates the NF-kappaB pathway but also alters the histone acetylation and deacetylation balance via post-translational modification of histone deacetylases (HDACs… CONTINUE READING

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