Modulation of sodium current kinetics by chlorpromazine in freshly-isolated striatal neurones of the adult guinea-pig.

Abstract

1. The neurones of the striatum were freshly dissociated from the adult guinea-pig brain by enzymatic and mechanical treatments. Sodium channel current kinetics in these neurones were measured using a whole cell variation of the patch-clamp technique. 2. Chlorpromazine, a neuroleptic, in micromolar concentrations reversibly reduced the amplitude of the… (More)

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Cite this paper

@article{Ogata1989ModulationOS, title={Modulation of sodium current kinetics by chlorpromazine in freshly-isolated striatal neurones of the adult guinea-pig.}, author={Nobuhiko Ogata and Hideharu Tatebayashi}, journal={British journal of pharmacology}, year={1989}, volume={98 4}, pages={1173-84} }