Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.

@article{Young2005ModulationOS,
  title={Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.},
  author={Katharine A Young and John H. Caldwell},
  journal={The Journal of physiology},
  year={2005},
  volume={565 Pt 2},
  pages={349-70}
}
Calmodulin (CaM) has been shown to modulate different ion channels, including voltage-gated sodium channels (NaChs). Using the yeast two-hybrid assay, we found an interaction between CaM and the C-terminal domains of adult skeletal (NaV1.4) and cardiac (NaV1.5) muscle NaChs. Effects of CaM were studied using sodium channels transiently expressed in CHO cells. Wild type CaM (CaM(WT)) caused a hyperpolarizing shift in the voltage dependence of activation and inactivation for NaV1.4 and activation… CONTINUE READING