Modulation of signaling proteins in cultured mast cells from chronic idiopathic urticaria patients

@article{Vonakis2004ModulationOS,
  title={Modulation of signaling proteins in cultured mast cells from chronic idiopathic urticaria patients},
  author={B. Vonakis and K. Nocka and Sudhir Rao and S. Gibbons and K. Vasagar and S. Saini},
  journal={The Journal of Allergy and Clinical Immunology},
  year={2004},
  volume={113}
}
Abstract Rationale Although mast cells and basophils have been implicated in the generation of urticarial lesions, signaling changes in the FceRI pathway are unexplored. In the present study, we compared SHIP-1, SHIP-2 and Syk levels from basophils and mast cells (MC) cultured from the peripheral blood of Chronic Idiopathic Urticaria (CIU) subjects. Methods Peripheral blood obtained from CIU and normal donors was fractionated by density gradient centrifugation. Basophils were purified by… Expand
1 Citations
Autoantibodies to the high-affinity IgE receptor in chronic urticaria: how important are they?
  • J. Sheikh
  • Medicine
  • Current opinion in allergy and clinical immunology
  • 2005
TLDR
The recent evidence discussed in this review helps to clarify the role of autoantibodies in some cases of urticaria, but also points towards other non-autoimmune mechanisms that might be pathogenic. Expand