Modulation of signal transducers and activators of transcription 1 and 3 signaling in melanoma by high-dose IFNalpha2b.

@article{Wang2007ModulationOS,
  title={Modulation of signal transducers and activators of transcription 1 and 3 signaling in melanoma by high-dose IFNalpha2b.},
  author={Wenjun Wang and Howard D. Edington and Uma N. M. Rao and Drazen Jukic and Stephanie R. Land and Soldano Ferrone and John Munn Kirkwood},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2007},
  volume={13 5},
  pages={1523-31}
}
PURPOSE The Janus-activated kinase/signal transducers and activators of transcription (STAT) pathway of IFN signaling is important to immunoregulation and tumor progression. STAT1 plays a prominent role in the effector immune response, whereas STAT3 is implicated in tumor progression and down-regulation of the response to type I IFNs. The goal of this study was to understand the effects of high-dose IFNalpha2b (HDI) in relation to the balance of pSTAT1 and pSTAT3. EXPERIMENTAL DESIGN We… CONTINUE READING

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