Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.

@article{Boulares1999ModulationOS,
  title={Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.},
  author={Hamid A. Boulares and Charles Giardina and Claire Laure Navarro and Edward A. Khairallah and Steven D. Cohen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={1999},
  volume={48 2},
  pages={
          264-74
        }
}
Acetaminophen (APAP) is a widely used analgesic and antipyretic that can lead to severe liver damage when taken at excessive doses. APAP toxicity results when cytochrome P450-generated APAP metabolites trigger an oxidative stress and covalently modify target proteins. APAP has also been reported to inhibit cells from completing S-phase through a cytochrome P450-independent mechanism, raising the possibility that APAP may directly suppress liver regeneration and repair. Here we show that APAP… CONTINUE READING

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