Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.

@article{Stevens1990ModulationOR,
  title={Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.},
  author={Victoria L Stevens and Nancy Owens and Elliott F. Winton and Joseph M. Kinkade and Alfred H. Merrill},
  journal={Cancer research},
  year={1990},
  volume={50 2},
  pages={222-6}
}
The human cell line HL-60 was used to investigate the role of protein kinase C in the regulation of retinoic acid-induced maturation of promyelocytic leukemia cells by growth and differentiation factors found in serum. Cells grown in serum-containing medium differentiated less than cells in serum-free medium due to several factors, including albumin binding of retinoic acid. Addition of an inhibitor (sphinganine) of protein kinase C, an enzyme that participates in cellular responses to many… CONTINUE READING
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