Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats.

@article{Hedrick1994ModulationOR,
  title={Modulation of respiratory rhythm by alpha 2-adrenoceptors in awake and anesthetized goats.},
  author={Michael S Hedrick and Mary Lou Ryan and Jose Anselmo Arango Pizarro and Gerald E. Bisgard},
  journal={Journal of applied physiology},
  year={1994},
  volume={77 2},
  pages={742-50}
}
The purpose of this study was to examine the effects of alpha 2-adrenoceptor agonists in the control of breathing with goats that were either awake (n = 7) or anesthetized and artificially ventilated (n = 11). Awake goats infused intravenously with either of the alpha 2-agonists clonidine (1.0-6.0 micrograms/kg) or guanabenz (15.0-63.0 micrograms/kg) exhibited two distinct ventilatory patterns. One pattern was characterized by tachypnea in which respiratory frequency and minute ventilation… CONTINUE READING

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