Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens.

@article{Matsuyama2005ModulationOR,
  title={Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens.},
  author={Hironori Matsuyama and Kan Sato and Yumi Nakamura and Katsumi Suzuki and Yukio Akiba},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1734 2},
  pages={136-42}
}
mRNA transcripts encoding multiple proteins from the cholesterol biosynthetic and uptake pathways in livers are controlled by sterol regulatory element binding protein-2 (SREBP-2), a membrane-bound mammalian transcription factor. The aims of the present study were to investigate whether SREBP-2 responds to plasma cholesterol levels and modulates expression of factors involved in the cholesterol metabolism of chickens. Supplementing the diets of chickens with 0.1% pravastatin, a drug used to… CONTINUE READING
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