Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.

@article{Cao2001ModulationOR,
  title={Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.},
  author={Yue Cao and John C. Dreixler and Jeffrey D Roizen and Michael T Roberts and Khaled M Houamed},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={296 3},
  pages={683-9}
}
Using the patch clamp technique we investigated the effects of the centrally acting muscle relaxant chlorzoxazone and three structurally related compounds, 1-ethyl-2-benzimidazolinone (1-EBIO), zoxazolamine, and 1,3-dihydro-1-[2-hydroxy-5-(triflu oromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one (NS 1619) on recombinant rat brain SK2 channels (rSK2 channels) expressed in HEK293 mammalian cells. SK channels are small conductance K(+) channels normally activated by a rise in… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 24 references

Stimulation of Cl(-) secretion by chlorzoxazone.

The Journal of pharmacology and experimental therapeutics • 2000
View 4 Excerpts
Highly Influenced

Activation of the human intermediate - conductance Ca 2 1 - activated K 1 channel by 1 - ethyl - 2 - benzimidazolinone is strongly Ca 2 1 - dependent

KA Pedersen, RL Schroder, B Skaaning-Jensen, D Strobaek, SP Olesen
Biochim Biophys Acta • 1999
View 4 Excerpts
Highly Influenced

Ca21dependent K1 channels in cerebellar granule cells

KA Pedersen, RL Schroder, +3 authors P Christophersen
1999
View 6 Excerpts
Highly Influenced

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